Favorskii rearrangement of some α-bromo-ketones
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چکیده
منابع مشابه
Stereocontrolled synthesis of kelsoene by the homo-favorskii rearrangement.
[reaction: see text] (+/-)-Kelsoene (4) has been synthesized from 2,5-dihydroanisole in 16 steps in 12.5% overall yield. The key step involves a base-catalyzed reaction of gamma-keto tosylate (5), which effects a homo-Favorskii rearrangement to 16 as well as the corresponding intramolecular S(N)2 product 15 from the enolate of 5. Ketone 15 can efficiently be isomerized to cyclobutanone 17 havin...
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ژورنال
عنوان ژورنال: J. Chem. Soc. D
سال: 1969
ISSN: 0577-6171
DOI: 10.1039/c29690000270